Higher Folic Acid By Solaray Predicts Moderately Higher Walk Or Run Distance for Population

Higher Folic Acid By Solaray Predicts Moderately Higher Walk Or Run Distance for Population

Contents

Variables

A
Folic Acid by Solaray 32
A
Walk or Run Distance 891

Categories

A
Treatments 9356
A
Physical Activity 1719

Actions

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Join Study
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Your Data

Tags

High Confidence
Moderate Effect Size
Positive Relationship
Population Study
cause image gauge image effect image
Participants reported a 14.4% average decrease in Walk Or Run Distance following above average Folic Acid By Solaray.

Abstract

<h5>Not Enough Shared Data</h5>Please create a study and share it with your friends so we can collect enough data to determine the effect of Folic Acid By Solaray on Walk Or Run Distance. <a href="https://web.quantimo.do/#/app/study-creation" title="Create a Study" class="create-study-button"> Create a Study </a> <h5>Solution: Create a Study</h5>Please create a study and share it with your friends so we can collect enough data to determine the effect of Folic Acid By Solaray on Walk Or Run Distance. <a href="https://web.quantimo.do/#/app/study-creation" title="Create a Study" class="create-study-button"> Create a Study </a>

Walk Or Run Distance was generally 12% higher than average after an average of 0 micrograms of Folic Acid By Solaray over the previous 7 days.

Aggregated data from 2 study participants suggests with a HIGH degree of confidence (p=0.169, 95% CI -1247.932 to 1248.792) that Folic Acid By Solaray has a moderately positive predictive relationship (R=0.43) with Walk Or Run Distance.

The highest quartile of Walk Or Run Distance measurements were observed following an average 130 micrograms Folic Acid By Solaray.

The lowest quartile of Walk Or Run Distance measurements were observed following an average 138 micrograms of Folic Acid By Solaray.

After an onset delay of 30 minutes, Walk Or Run Distance is typically 8% lower than average over the 7 days following around 138 micrograms of Folic Acid By Solaray Folic Acid By Solaray.

Keywords: Folic Acid By Solaray, Walk Or Run Distance, N-of-1 trials, real-world evidence, causal inference, observational study

Preliminary: Based on 2 participants. Results may change as more data is collected.

Results

Primary Findings

Analysis of 976 paired observations from 2 participants revealed a minimal reduction in Walk Or Run Distance following above-average Folic Acid By Solaray exposure.

0.0%
Change from Baseline
Minimal effect on Walk Or Run Distance
0.04
Predictor Impact Score
Insufficient evidence for causal relationship

Supporting Statistics

High
Confidence
0.430
Correlation (r)
p = 0.236
Significance
z = 0.00
Effect Magnitude
φ = 1.00
Temporality

What This Means

When participants had above-average Folic Acid By Solaray:

  • Walk Or Run Distance decreased by 0.0% on average
  • Temporal analysis supports Folic Acid By Solaray as the predictor (not the outcome)

Interpreting the Predictor Impact Score

The Predictor Impact Score (PIS) integrates multiple Bradford Hill causal criteria into a single metric. Use this guide to interpret the score:

PIS Range Interpretation Recommended Action
≥ 0.5 Strong evidence High priority for RCT validation
0.3 - 0.5 Moderate evidence Consider for experimental investigation
0.1 - 0.3 Weak evidence Monitor for additional data
< 0.1 Insufficient evidence Low priority; may be noise

Note: PIS is a prioritization heuristic, not proof of causation. High scores indicate relationships worth investigating, not confirmed causal effects. With only 2 participants, these scores are preliminary and will become more reliable as additional data is collected.

Optimal Daily Values

No clear dose-response relationship detected. The Folic Acid By Solaray values associated with high and low Walk Or Run Distance are too similar to provide meaningful dosing guidance. This may indicate a threshold effect (any amount works equally well), no effect, or insufficient data variance. With more participants, a clearer pattern may emerge.

Population Correlation

Folic Acid By Solaray Distribution

Walk Or Run Distance Distribution

Relationship Analysis

Statistical Summary

Relationship Statistics

Property Value
Cause Variable Name Folic Acid By Solaray
Effect Variable Name Walk Or Run Distance
Sinn Predictive Coefficient 0.038972888736503
Confidence Level HIGH
Confidence Interval 1248.3616345974
Forward Pearson Predictive Coefficient 0.43
Critical T Value 1.6715
Average Folic Acid By Solaray Over Previous 7 days Before ABOVE Average Walk Or Run Distance 130 micrograms
Average Folic Acid By Solaray Over Previous 7 days Before BELOW Average Walk Or Run Distance 138 micrograms
Duration of Action 7 days
Effect Size moderately positive
Number of Paired Measurements 976
Optimal Pearson Product 0.0032285020250887
P Value 0.16909377033938
Statistical Significance 0.2363
Strength of Relationship 1248.3616345974
Study Type population
Analysis Performed At 2026-01-04
Number of Participants 2

Folic Acid by Solaray Info

Property Value
Variable Name Folic Acid By Solaray
Aggregation Method MEAN
Analysis Performed At 2020-09-22
Duration of Action 21 days
Filling Value 0
Kurtosis 1.9863095840515
Mean 636.84 micrograms
Median 800 micrograms
Minimum Allowed Value 0 micrograms
Number of Aggregate Predictors 0
Number of Aggregate Outcomes 32
Number of Measurements 69
Number of Measurements (including those generated by tagged, joined, or child variables) 69
Public true
Onset Delay 30 minutes
Standard Deviation 621.48311874421
Unit Micrograms
User Variables 2
UPC 076280043525
Variable Category Treatments
Variable ID 86637
Variance 386241.26688403

Walk or Run Distance Info

Property Value
Variable Name Walk Or Run Distance
Aggregation Method SUM
Analysis Performed At 2020-09-11
Duration of Action 7 days
Kurtosis 18.843598392696
Maximum Allowed Value 175000 meters
Mean 3558.0042632859 meters
Median 3158.90008036 meters
Minimum Allowed Value 1 meters
Number of Aggregate Predictors 642
Number of Aggregate Outcomes 249
Number of Measurements 123085
Number of Measurements (including those generated by tagged, joined, or child variables) 87104
Public true
Onset Delay 0 seconds
Standard Deviation 2361.166855319
Unit Meters
User Variables 378
UPC 744960759935
Variable Category Physical Activity
Variable ID 1304
Variance 9674812.3231088

Introduction

Background

Folic Acid By Solaray (Treatments) and Walk Or Run Distance (Physical Activity) are both important factors in understanding human health and well-being. This study investigates the relationship between these two variables using real-world observational data.

Traditional randomized controlled trials (RCTs), while the gold standard for causal inference, are often impractical, expensive, or unethical for studying many health relationships. Aggregated N-of-1 observational studies offer a complementary approach that leverages within-subject comparisons across large populations to identify meaningful patterns.

Research Question

Does Folic Acid By Solaray affect Walk Or Run Distance?

Additionally, we seek to determine:

  1. What is the direction and magnitude of any effect?
  2. How confident can we be in this relationship based on the available data?
  3. What are the optimal levels of Folic Acid By Solaray for maximizing Walk Or Run Distance?

Study Objective

The objective of this study is to determine the nature of the relationship (if any) between Folic Acid By Solaray and Walk Or Run Distance. Additionally, we attempt to determine the Folic Acid By Solaray values most likely to produce optimal Walk Or Run Distance values.

Study Overview

This is a population-level observational study using aggregated N-of-1 methodology. By aggregating individual N-of-1 experiments, we can identify population-level patterns while accounting for the substantial individual variation that exists in most health relationships. Effect sizes are reported as percent change from baseline, enabling intuitive interpretation and comparison across different measures.

Full Methodology: Framework for Real-World Evidence-Based Pharmacovigilance: Aggregated N-of-1 Trials for Quantifying Treatment Effects

Discussion

Interpretation of Findings

Participants experienced a 0.0% reduction in Walk Or Run Distance following above-average Folic Acid By Solaray exposure. The Predictor Impact Score (PIS) of 0.04 indicates insufficient evidence for a causal relationship.

Statistical Significance

Using a two-tailed t-test with alpha = 0.05, it was determined that the change in Walk Or Run Distance is statistically significant at a 95% confidence interval. The p-value of 0.2363 indicates there is less than a 23.63% probability that this result occurred by chance.

T-Test Details
Observed t-value: 2.188
Critical t-value: 1.672

Since t = 2.19 > 1.67, we reject the null hypothesis.

Biological Plausibility

A plausible bio-chemical mechanism between predictor and outcome is critical for interpreting observational findings. This is where human judgment excels beyond statistical analysis.

Community feedback on the biological plausibility of this relationship is still being collected. Consider the known mechanisms by which Folic Acid By Solaray might influence Walk Or Run Distance.

Bradford Hill Criteria Assessment

The Bradford Hill criteria provide a framework for assessing causality in observational studies. Our methodology operationalizes six of the nine criteria through the Predictor Impact Score (PIS):

Criterion How Addressed Metric
Strength Effect size magnitude Percent change from baseline (Δ%), z-score
Consistency Cross-participant replication Number of users (N), number of pairs (n)
Temporality Predictor precedes outcome Temporality factor (φ), onset delay (δ > 0)
Biological Gradient Dose-response relationship Gradient coefficient (φgradient)
Plausibility Biological mechanism assessment Community votes on mechanism plausibility
Specificity Category appropriateness Interest factor (finterest)

Predictor Impact Score (PIS)

The PIS integrates multiple Bradford Hill criteria into a composite metric quantifying how reliably a predictor affects an outcome. Higher scores indicate stronger evidence:

Population-Level PIS:

$$\text{PIS}_{\text{agg}} = |r_{\text{forward}}| \cdot w \cdot \phi_{\text{users}} \cdot \phi_{\text{pairs}} \cdot \phi_{\text{change}} \cdot \phi_{\text{gradient}}$$

Where φ-factors are saturation functions approaching 1 as evidence accumulates:

  • φusers = 1 - e-N/10 (user saturation)
  • φpairs = 1 - e-n/nsig (pair saturation)
  • φchange = 1 - e-Δspread/Δsig (effect spread saturation)
  • w = weighted average of plausibility votes

Temporality Assessment

We assess evidence for correct causal direction using the temporality factor:

$$\phi_{\text{temporal}} = \frac{|r_{\text{forward}}|}{|r_{\text{forward}}| + |r_{\text{reverse}}|}$$

Values approaching 1 indicate the predictor precedes the outcome (supporting causation); values near 0.5 suggest ambiguous directionality; values near 0 suggest reverse causation or confounding by indication.

Limitations

The accuracy of this study may be limited by the fact that <h5>Not Enough Shared Data</h5>Please create a study and share it with your friends so we can collect enough data to determine the effect of Folic Acid By Solaray on Walk Or Run Distance. <a href="https://web.quantimo.do/#/app/study-creation" title="Create a Study" class="create-study-button"> Create a Study </a> <h5>Solution: Create a Study</h5>Please create a study and share it with your friends so we can collect enough data to determine the effect of Folic Acid By Solaray on Walk Or Run Distance. <a href="https://web.quantimo.do/#/app/study-creation" title="Create a Study" class="create-study-button"> Create a Study </a> . A greater amount of data and more variance in the data would help to resolve this issue.

As with any observational study, correlation does not prove causation. Key limitations include:

  • Unmeasured confounders: Variables not tracked may influence results
  • Self-selection bias: Health trackers may differ from the general population
  • Measurement error: Self-reported data may contain recall bias
  • Confounding by indication: Sicker individuals may use more treatments

However, within-subject comparison and temporal precedence analysis partially mitigate these limitations. If the relationship is merely coincidental, as participants independently modify their Folic Acid By Solaray values, the observed strength will decline over time. Spurious correlations naturally dissipate as more data is collected.

Future Directions

Future research should examine:

  • Subgroup analyses to identify individual differences in response
  • Potential confounders and mediators of the observed relationship
  • Optimal dosing and timing for Folic Acid By Solaray
  • Confirmation through prospective or randomized designs
  • Biological mechanisms underlying the observed effects

Conclusion

📊 Preliminary Findings: With 2 participants, these results are based on limited data. Effect sizes and confidence will improve as more participants contribute data. Consider these findings directional rather than definitive.

Above-average Folic Acid By Solaray was associated with a 0.0% reduction in Walk Or Run Distance—a minimal effect. The Predictor Impact Score of 0.04 indicates this relationship is requiring additional data before conclusions.

Bottom Line: Based on a PIS of 0.04 and a 0.0% effect size, this relationship currently lacks sufficient evidence. Continue monitoring as more data becomes available. Note: These conclusions may strengthen or change direction as more data is collected.

These findings contribute to our understanding of how Folic Acid By Solaray may influence Walk Or Run Distance in real-world conditions. While preliminary, these results may inform future research directions. As more participants contribute data, the reliability and precision of these findings will improve substantially.

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Methods

Study Design

This study is based on data donated by 2 participants. Thus, the study design is equivalent to the aggregation of 2 separate n=1 observational natural experiments.

This within-subject design is powerful because it controls for all stable individual characteristics (genetics, baseline health status, socioeconomic factors) that might otherwise confound the relationship between variables.

Data Analysis

Temporal Assumptions

The analysis incorporates temporal assumptions about the relationship between variables:

  • Onset Delay: It was assumed that 30 minutes would pass before a change in Folic Acid By Solaray would produce an observable change in Walk Or Run Distance.
  • Duration of Action: It was assumed that Folic Acid By Solaray could produce an observable change in Walk Or Run Distance for as much as 7 days after the stimulus event.

Statistical Methods

For each participant, we calculated the Pearson correlation coefficient between Folic Acid By Solaray values and subsequent Walk Or Run Distance values. Individual correlations were then aggregated using Fisher's z-transformation to produce a population-level estimate:

Individual Correlation:

$$r_i = \frac{\sum(x_{ij} - \bar{x}_i)(y_{ij} - \bar{y}_i)}{\sqrt{\sum(x_{ij} - \bar{x}_i)^2 \sum(y_{ij} - \bar{y}_i)^2}}$$

Fisher's Z-Transformation:

$$z_i = \frac{1}{2} \ln\left(\frac{1 + r_i}{1 - r_i}\right)$$

Aggregated Correlation:

$$\bar{r} = \tanh(\bar{z}) \quad \text{where} \quad \bar{z} = \frac{1}{N}\sum_{i=1}^{N} z_i$$

Effect Size Calculation

Effect sizes are reported as percent change from baseline. For each participant, we compare the outcome following above-average predictor values to the overall baseline outcome:

$$\Delta\%_{\text{baseline}} = \frac{\bar{O}_{\text{follow-up}} - \bar{O}_{\text{baseline}}}{\bar{O}_{\text{baseline}}} \times 100$$

Effect Magnitude (Z-Score)

To assess effect magnitude relative to natural variability, we calculate the z-score:

$$z = \frac{|\Delta\%_{\text{baseline}}|}{\text{RSD}_{\text{baseline}}}$$

where RSDbaseline is the relative standard deviation of outcome during baseline period

A z-score > 2 indicates statistical significance (p < 0.05), meaning the observed change exceeds typical baseline fluctuation and is unlikely due to random variation.

Statistical Significance

Correlation significance is assessed using a two-tailed t-test:

$$t = \frac{r\sqrt{n-2}}{\sqrt{1-r^2}}$$

We reject the null hypothesis (ρ = 0) at α = 0.05 when |t| exceeds the critical value, providing statistical evidence that the observed relationship is not due to chance.

Data Sources

Folic Acid By Solaray data was primarily collected using QuantiModo. QuantiModo allows you to easily track mood, symptoms, or any outcome you want to optimize in a fraction of a second. You can also import your data from over 30 other apps and devices. QuantiModo then analyzes your data to identify which hidden factors are most likely to be influencing your mood or symptoms.

Walk Or Run Distance data was primarily collected using Fitbit. Fitbit makes activity tracking easy and automatic.

Data Quality

Data quality measures were applied to ensure reliable results:

  • Minimum Data Requirement: Only participants with sufficient paired observations were included in the analysis.
  • Outlier Handling: Extreme values were winsorized to reduce the influence of measurement errors.
  • Missing Data: Days with missing values were handled using appropriate filling strategies based on the variable type.
  • Test User Exclusion: Test accounts and invalid users were excluded from all analyses.

Principal Investigator

Program & Methods

Mike P. Sinn
Sinn, M. P.

Designed and implemented data collection, aggregation, causal inference pipeline, and automated study generation framework. Developed the Predictor Impact Score methodology operationalizing Bradford Hill criteria for ranking causal relationships in observational data. When he tells people this at parties, they usually say they have to go check on their car.

Individual study outputs are automated, reproducible, and open to external audit. (Which I would seriously recommend.)

Contact

Cite This Study

APA Format
Sinn, M. P. (2026). Causal Analysis: Does Folic Acid By Solaray Affect Walk Or Run Distance?. The Journal of Citizen Science. https://studies.crowdsourcingcures.org/study/cause-86637-effect-1304-population-study
BibTeX 
@misc{sinn_cause_86637_effect_1304_population_study_2026,
  author = {Sinn, Mike P.},
  title = {Causal Analysis: Does Folic Acid By Solaray Affect Walk Or Run Distance?},
  year = {2026},
  publisher = {The Journal of Citizen Science},
  url = {https://studies.crowdsourcingcures.org/study/cause-86637-effect-1304-population-study},
  note = {Accessed: January 6, 2026}
}
Chicago/Turabian
Sinn, Mike P. "Causal Analysis: Does Folic Acid By Solaray Affect Walk Or Run Distance?." The Journal of Citizen Science. Accessed January 6, 2026. https://studies.crowdsourcingcures.org/study/cause-86637-effect-1304-population-study.
Harvard
Sinn, M.P., 2026. Causal Analysis: Does Folic Acid By Solaray Affect Walk Or Run Distance?. [Aggregated N-of-1 Study] The Journal of Citizen Science. Available at: https://studies.crowdsourcingcures.org/study/cause-86637-effect-1304-population-study [Accessed January 6, 2026].

Study Type: Aggregated N-of-1 Observational Mega-Study
Evidence Level: Level II (Real-World Evidence)
Methodology: Bradford Hill Criteria with Predictor Impact Score (PIS)

References

This framework was originally developed in 2013 based on the Bradford Hill criteria. Subsequent literature has independently validated similar approaches to causal inference from observational data:

  1. Hill, A.B. (1965). The environment and disease: association or causation? Proceedings of the Royal Society of Medicine, 58(5), 295-300. [Bradford Hill criteria]
  2. Lillie, E.O., et al. (2011). The n-of-1 clinical trial: the ultimate strategy for individualizing medicine? Personalized Medicine, 8(2), 161-173. [N-of-1 methodology]
  3. Pearl, J. (2009). Causality: Models, Reasoning, and Inference . Cambridge University Press. [Causal inference]
  4. Hernán, M.A., & Robins, J.M. (2020). Causal Inference: What If . Chapman & Hall/CRC. [Free textbook]
  5. FDA (2018). Framework for FDA's Real-World Evidence Program . U.S. Food and Drug Administration. [Regulatory context]
  6. Duan, N., et al. (2013). Single-patient (n-of-1) trials: a pragmatic clinical decision methodology . Journal of Clinical Epidemiology, 66(8), S21-S28.
  7. Platt, R., et al. (2018). The FDA Sentinel Initiative—an evolving national resource . New England Journal of Medicine, 379(22), 2091-2093.

This information is for research and educational purposes only, not medical advice. Consult a healthcare provider before making health decisions. Terms of Service

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