Higher Cal-Mag By Natura Predicts Moderately Higher Hostility for Population

Higher Cal-Mag By Natura Predicts Moderately Higher Hostility for Population

Contents

Variables

A
Cal-Mag by Natura 32
A
Hostility 1794

Categories

A
Treatments 9356
A
Emotions 2028

Actions

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Your Data

Tags

Medium Confidence
Weak Effect Size
Positive Relationship
Population Study
cause image gauge image effect image
Participants reported a 21.8% average increase in Hostility following above average Cal-Mag By Natura.

Abstract

Hostility was generally 26% higher than average after 0 tablets of Cal-Mag By Natura per 21 days.

Aggregated data from 2 study participants suggests with a MEDIUM degree of confidence (p=0.0202, 95% CI 0.043 to 0.63) that Cal-Mag By Natura has a moderately positive predictive relationship (R=0.336) with Hostility.

The highest quartile of Hostility measurements were observed following an average 45.2 tablets Cal-Mag By Natura per day.

The lowest quartile of Hostility measurements were observed following an average 26.8 tablets of Cal-Mag By Natura per day.

After an onset delay of 30 minutes, Hostility is typically 12% lower than average over the 21 days following around 26.8 tablets of Cal-Mag By Natura Cal-Mag By Natura.

Keywords: Cal-Mag By Natura, Hostility, N-of-1 trials, real-world evidence, causal inference, observational study

Preliminary: Based on 2 participants. Results may change as more data is collected.

Results

Primary Findings

Analysis of 56 paired observations from 2 participants revealed a substantial improvement in Hostility following above-average Cal-Mag By Natura exposure.

+26.0%
Change from Baseline
Substantial effect on Hostility
0.06
Predictor Impact Score
Insufficient evidence for causal relationship

Supporting Statistics

Low
Confidence
0.336
Correlation (r)
p = 0.493
Significance
z = 0.83
Effect Magnitude
φ = 1.00
Temporality

What This Means

When participants had above-average Cal-Mag By Natura:

  • Hostility increased by 26.0% on average
  • Temporal analysis supports Cal-Mag By Natura as the predictor (not the outcome)

Interpreting the Predictor Impact Score

The Predictor Impact Score (PIS) integrates multiple Bradford Hill causal criteria into a single metric. Use this guide to interpret the score:

PIS Range Interpretation Recommended Action
≥ 0.5 Strong evidence High priority for RCT validation
0.3 - 0.5 Moderate evidence Consider for experimental investigation
0.1 - 0.3 Weak evidence Monitor for additional data
< 0.1 Insufficient evidence Low priority; may be noise

Note: PIS is a prioritization heuristic, not proof of causation. High scores indicate relationships worth investigating, not confirmed causal effects. With only 2 participants, these scores are preliminary and will become more reliable as additional data is collected.

Optimal Daily Values (Precision Dosing)

Based on the observed relationship, we can estimate the predictor values associated with the best and worst outcomes. These values enable personalized dosing recommendations.

⚠️ Preliminary Data: With 2 participants and 56 observations, these optimal values are preliminary estimates. As more data is collected, precision will improve significantly.

56.0 tablets
Value Predicting Higher Hostility
Average Cal-Mag By Natura when Hostility exceeded its mean
0.0 tablets
Value Predicting Lower Hostility
Average Cal-Mag By Natura when Hostility was below its mean

What This Suggests

Hostility tended to be highest when Cal-Mag By Natura was around 56.0 tablets.

Important: These values reflect correlations, not guaranteed causal effects. Individual responses may vary. Use as a starting point for personal experimentation, not as a definitive prescription. Consult healthcare providers before making treatment decisions.

Population Correlation

Cal-Mag By Natura Distribution

Hostility Distribution

Relationship Analysis

Statistical Summary

Relationship Statistics

Property Value
Cause Variable Name Cal-Mag By Natura
Effect Variable Name Hostility
Sinn Predictive Coefficient 0.060960845138154
Confidence Level MEDIUM
Confidence Interval 0.29334
Forward Pearson Predictive Coefficient 0.3363
Critical T Value 1.671
Total Cal- Mag By Natura Over Previous 21 days Before ABOVE Average Hostility 45.2 tablets
Total Cal- Mag By Natura Over Previous 21 days Before BELOW Average Hostility 26.8 tablets
Duration of Action 21 days
Effect Size moderately positive
Number of Paired Measurements 56
Optimal Pearson Product 0.23843523524109
P Value 0.020169
Statistical Significance 0.4926
Strength of Relationship 0.29334
Study Type population
Analysis Performed At 2026-01-04
Number of Participants 2

Cal-Mag by Natura Info

Property Value
Variable Name Cal-Mag By Natura
Aggregation Method SUM
Analysis Performed At 2020-09-17
Duration of Action 21 days
Filling Value 0
Kurtosis 1.8596935467438
Maximum Allowed Value 20 tablets
Mean 1.0471859060403 tablets
Median 0 tablets
Minimum Allowed Value 0 tablets
Number of Aggregate Predictors 0
Number of Aggregate Outcomes 32
Number of Measurements 149
Number of Measurements (including those generated by tagged, joined, or child variables) 149
Public true
Onset Delay 30 minutes
Standard Deviation 1.5887655032055
Unit Tablets
User Variables 2
UPC 040647296473
Variable Category Treatments
Variable ID 84965
Variance 2.5241758241758

Hostility Info

Property Value
Variable Name Hostility
Aggregation Method MEAN
Analysis Performed At 2020-09-11
Duration of Action 24 hours
Kurtosis 3.2955086179779
Maximum Allowed Value 5 out of 5
Mean 2.0950173666087 out of 5
Median 2.0214201534985 out of 5
Minimum Allowed Value 1 out of 5
Number of Aggregate Predictors 1646
Number of Aggregate Outcomes 148
Number of Measurements 24265
Number of Measurements (including those generated by tagged, joined, or child variables) 23622
Public true
Onset Delay 0 seconds
Standard Deviation 0.4788482547512
Unit 1 to 5 Rating
User Variables 1458
UPC 780456428275
Variable Category Emotions
Variable ID 1344
Variance 0.57308207019228

Introduction

Background

Cal-Mag By Natura (Treatments) and Hostility (Emotions) are both important factors in understanding human health and well-being. This study investigates the relationship between these two variables using real-world observational data.

Traditional randomized controlled trials (RCTs), while the gold standard for causal inference, are often impractical, expensive, or unethical for studying many health relationships. Aggregated N-of-1 observational studies offer a complementary approach that leverages within-subject comparisons across large populations to identify meaningful patterns.

Research Question

Does Cal-Mag By Natura affect Hostility?

Additionally, we seek to determine:

  1. What is the direction and magnitude of any effect?
  2. How confident can we be in this relationship based on the available data?
  3. What are the optimal levels of Cal-Mag By Natura for maximizing Hostility?

Study Objective

The objective of this study is to determine the nature of the relationship (if any) between Cal-Mag By Natura and Hostility. Additionally, we attempt to determine the Cal-Mag By Natura values most likely to produce optimal Hostility values.

Study Overview

This is a population-level observational study using aggregated N-of-1 methodology. By aggregating individual N-of-1 experiments, we can identify population-level patterns while accounting for the substantial individual variation that exists in most health relationships. Effect sizes are reported as percent change from baseline, enabling intuitive interpretation and comparison across different measures.

Full Methodology: Framework for Real-World Evidence-Based Pharmacovigilance: Aggregated N-of-1 Trials for Quantifying Treatment Effects

Discussion

Interpretation of Findings

Participants experienced a 26.0% improvement in Hostility following above-average Cal-Mag By Natura exposure. The Predictor Impact Score (PIS) of 0.06 indicates insufficient evidence for a causal relationship.

Statistical Significance

Using a two-tailed t-test with alpha = 0.05, it was determined that the change in Hostility is statistically significant at a 95% confidence interval. The p-value of 0.4926 indicates there is less than a 49.26% probability that this result occurred by chance.

After treatment, a 21.8% increase (0.429 out of 5) from the mean baseline 1.65 out of 5 was observed. The relative standard deviation at baseline was 31.5%. The observed change was 0.82802 times the standard deviation.

A common rule of thumb considers a change greater than twice the baseline standard deviation on two separate pre-post experiments may be considered significant. This occurrence would have only a 5% likelihood of resulting from random fluctuation (a p-value < 0.05).

T-Test Details
Observed t-value: 2.443
Critical t-value: 1.671

Since t = 2.44 > 1.67, we reject the null hypothesis.

Biological Plausibility

A plausible bio-chemical mechanism between predictor and outcome is critical for interpreting observational findings. This is where human judgment excels beyond statistical analysis.

Community feedback on the biological plausibility of this relationship is still being collected. Consider the known mechanisms by which Cal-Mag By Natura might influence Hostility.

Bradford Hill Criteria Assessment

The Bradford Hill criteria provide a framework for assessing causality in observational studies. Our methodology operationalizes six of the nine criteria through the Predictor Impact Score (PIS):

Criterion How Addressed Metric
Strength Effect size magnitude Percent change from baseline (Δ%), z-score
Consistency Cross-participant replication Number of users (N), number of pairs (n)
Temporality Predictor precedes outcome Temporality factor (φ), onset delay (δ > 0)
Biological Gradient Dose-response relationship Gradient coefficient (φgradient)
Plausibility Biological mechanism assessment Community votes on mechanism plausibility
Specificity Category appropriateness Interest factor (finterest)

Predictor Impact Score (PIS)

The PIS integrates multiple Bradford Hill criteria into a composite metric quantifying how reliably a predictor affects an outcome. Higher scores indicate stronger evidence:

Population-Level PIS:

$$\text{PIS}_{\text{agg}} = |r_{\text{forward}}| \cdot w \cdot \phi_{\text{users}} \cdot \phi_{\text{pairs}} \cdot \phi_{\text{change}} \cdot \phi_{\text{gradient}}$$

Where φ-factors are saturation functions approaching 1 as evidence accumulates:

  • φusers = 1 - e-N/10 (user saturation)
  • φpairs = 1 - e-n/nsig (pair saturation)
  • φchange = 1 - e-Δspread/Δsig (effect spread saturation)
  • w = weighted average of plausibility votes

Temporality Assessment

We assess evidence for correct causal direction using the temporality factor:

$$\phi_{\text{temporal}} = \frac{|r_{\text{forward}}|}{|r_{\text{forward}}| + |r_{\text{reverse}}|}$$

Values approaching 1 indicate the predictor precedes the outcome (supporting causation); values near 0.5 suggest ambiguous directionality; values near 0 suggest reverse causation or confounding by indication.

Limitations

As with any observational study, correlation does not prove causation. Key limitations include:

  • Unmeasured confounders: Variables not tracked may influence results
  • Self-selection bias: Health trackers may differ from the general population
  • Measurement error: Self-reported data may contain recall bias
  • Confounding by indication: Sicker individuals may use more treatments

However, within-subject comparison and temporal precedence analysis partially mitigate these limitations. If the relationship is merely coincidental, as participants independently modify their Cal-Mag By Natura values, the observed strength will decline over time. Spurious correlations naturally dissipate as more data is collected.

Future Directions

Future research should examine:

  • Subgroup analyses to identify individual differences in response
  • Potential confounders and mediators of the observed relationship
  • Optimal dosing and timing for Cal-Mag By Natura
  • Confirmation through prospective or randomized designs
  • Biological mechanisms underlying the observed effects

Conclusion

📊 Preliminary Findings: With 2 participants, these results are based on limited data. Effect sizes and confidence will improve as more participants contribute data. Consider these findings directional rather than definitive.

Above-average Cal-Mag By Natura was associated with a 26.0% improvement in Hostility—a substantial effect. The Predictor Impact Score of 0.06 indicates this relationship is requiring additional data before conclusions.

Bottom Line: Based on a PIS of 0.06 and a 26.0% effect size, this relationship currently lacks sufficient evidence. Continue monitoring as more data becomes available. Note: These conclusions may strengthen or change direction as more data is collected.

These findings contribute to our understanding of how Cal-Mag By Natura may influence Hostility in real-world conditions. While preliminary, these results may inform future research directions. As more participants contribute data, the reliability and precision of these findings will improve substantially.

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Methods

Study Design

This study is based on data donated by 2 participants. Thus, the study design is equivalent to the aggregation of 2 separate n=1 observational natural experiments.

This within-subject design is powerful because it controls for all stable individual characteristics (genetics, baseline health status, socioeconomic factors) that might otherwise confound the relationship between variables.

Data Analysis

Temporal Assumptions

The analysis incorporates temporal assumptions about the relationship between variables:

  • Onset Delay: It was assumed that 30 minutes would pass before a change in Cal-Mag By Natura would produce an observable change in Hostility.
  • Duration of Action: It was assumed that Cal-Mag By Natura could produce an observable change in Hostility for as much as 21 days after the stimulus event.

Statistical Methods

For each participant, we calculated the Pearson correlation coefficient between Cal-Mag By Natura values and subsequent Hostility values. Individual correlations were then aggregated using Fisher's z-transformation to produce a population-level estimate:

Individual Correlation:

$$r_i = \frac{\sum(x_{ij} - \bar{x}_i)(y_{ij} - \bar{y}_i)}{\sqrt{\sum(x_{ij} - \bar{x}_i)^2 \sum(y_{ij} - \bar{y}_i)^2}}$$

Fisher's Z-Transformation:

$$z_i = \frac{1}{2} \ln\left(\frac{1 + r_i}{1 - r_i}\right)$$

Aggregated Correlation:

$$\bar{r} = \tanh(\bar{z}) \quad \text{where} \quad \bar{z} = \frac{1}{N}\sum_{i=1}^{N} z_i$$

Effect Size Calculation

Effect sizes are reported as percent change from baseline. For each participant, we compare the outcome following above-average predictor values to the overall baseline outcome:

$$\Delta\%_{\text{baseline}} = \frac{\bar{O}_{\text{follow-up}} - \bar{O}_{\text{baseline}}}{\bar{O}_{\text{baseline}}} \times 100$$

Effect Magnitude (Z-Score)

To assess effect magnitude relative to natural variability, we calculate the z-score:

$$z = \frac{|\Delta\%_{\text{baseline}}|}{\text{RSD}_{\text{baseline}}}$$

where RSDbaseline is the relative standard deviation of outcome during baseline period

A z-score > 2 indicates statistical significance (p < 0.05), meaning the observed change exceeds typical baseline fluctuation and is unlikely due to random variation.

Statistical Significance

Correlation significance is assessed using a two-tailed t-test:

$$t = \frac{r\sqrt{n-2}}{\sqrt{1-r^2}}$$

We reject the null hypothesis (ρ = 0) at α = 0.05 when |t| exceeds the critical value, providing statistical evidence that the observed relationship is not due to chance.

Data Sources

Cal-Mag By Natura data was primarily collected using QuantiModo. QuantiModo allows you to easily track mood, symptoms, or any outcome you want to optimize in a fraction of a second. You can also import your data from over 30 other apps and devices. QuantiModo then analyzes your data to identify which hidden factors are most likely to be influencing your mood or symptoms.

Hostility data was primarily collected using QuantiModo. QuantiModo allows you to easily track mood, symptoms, or any outcome you want to optimize in a fraction of a second. You can also import your data from over 30 other apps and devices. QuantiModo then analyzes your data to identify which hidden factors are most likely to be influencing your mood or symptoms.

Data Quality

Data quality measures were applied to ensure reliable results:

  • Minimum Data Requirement: Only participants with sufficient paired observations were included in the analysis.
  • Outlier Handling: Extreme values were winsorized to reduce the influence of measurement errors.
  • Missing Data: Days with missing values were handled using appropriate filling strategies based on the variable type.
  • Test User Exclusion: Test accounts and invalid users were excluded from all analyses.

Principal Investigator

Program & Methods

Mike P. Sinn
Sinn, M. P.

Designed and implemented data collection, aggregation, causal inference pipeline, and automated study generation framework. Developed the Predictor Impact Score methodology operationalizing Bradford Hill criteria for ranking causal relationships in observational data. When he tells people this at parties, they usually say they have to go check on their car.

Individual study outputs are automated, reproducible, and open to external audit. (Which I would seriously recommend.)

Contact

Cite This Study

APA Format
Sinn, M. P. (2026). Causal Analysis: Does Cal-Mag By Natura Affect Hostility?. The Journal of Citizen Science. https://studies.crowdsourcingcures.org/study/cause-84965-effect-1344-population-study
BibTeX 
@misc{sinn_cause_84965_effect_1344_population_study_2026,
  author = {Sinn, Mike P.},
  title = {Causal Analysis: Does Cal-Mag By Natura Affect Hostility?},
  year = {2026},
  publisher = {The Journal of Citizen Science},
  url = {https://studies.crowdsourcingcures.org/study/cause-84965-effect-1344-population-study},
  note = {Accessed: January 9, 2026}
}
Chicago/Turabian
Sinn, Mike P. "Causal Analysis: Does Cal-Mag By Natura Affect Hostility?." The Journal of Citizen Science. Accessed January 9, 2026. https://studies.crowdsourcingcures.org/study/cause-84965-effect-1344-population-study.
Harvard
Sinn, M.P., 2026. Causal Analysis: Does Cal-Mag By Natura Affect Hostility?. [Aggregated N-of-1 Study] The Journal of Citizen Science. Available at: https://studies.crowdsourcingcures.org/study/cause-84965-effect-1344-population-study [Accessed January 9, 2026].

Study Type: Aggregated N-of-1 Observational Mega-Study
Evidence Level: Level II (Real-World Evidence)
Methodology: Bradford Hill Criteria with Predictor Impact Score (PIS)

References

This framework was originally developed in 2013 based on the Bradford Hill criteria. Subsequent literature has independently validated similar approaches to causal inference from observational data:

  1. Hill, A.B. (1965). The environment and disease: association or causation? Proceedings of the Royal Society of Medicine, 58(5), 295-300. [Bradford Hill criteria]
  2. Lillie, E.O., et al. (2011). The n-of-1 clinical trial: the ultimate strategy for individualizing medicine? Personalized Medicine, 8(2), 161-173. [N-of-1 methodology]
  3. Pearl, J. (2009). Causality: Models, Reasoning, and Inference . Cambridge University Press. [Causal inference]
  4. Hernán, M.A., & Robins, J.M. (2020). Causal Inference: What If . Chapman & Hall/CRC. [Free textbook]
  5. FDA (2018). Framework for FDA's Real-World Evidence Program . U.S. Food and Drug Administration. [Regulatory context]
  6. Duan, N., et al. (2013). Single-patient (n-of-1) trials: a pragmatic clinical decision methodology . Journal of Clinical Epidemiology, 66(8), S21-S28.
  7. Platt, R., et al. (2018). The FDA Sentinel Initiative—an evolving national resource . New England Journal of Medicine, 379(22), 2091-2093.

This information is for research and educational purposes only, not medical advice. Consult a healthcare provider before making health decisions. Terms of Service

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