Abstract
Loneliness was generally 2.7333% higher than average after 6 minutes of Engineering & Technology Activities per 7 days.
Aggregated data from 3 study participants suggests with a LOW degree of confidence (p=0.28, 95% CI -0.307 to 0.453) that Engineering & Technology Activities has a very weakly positive predictive relationship (R=0.0732) with Loneliness.
The highest quartile of Loneliness measurements were observed following an average 8 minutes Engineering & Technology Activities per day.
The lowest quartile of Loneliness measurements were observed following an average 6 minutes of Engineering & Technology Activities per day.
After an onset delay of 0 seconds, Loneliness is typically 2% lower than average over the 7 days following around 6 minutes of Engineering & Technology Activities Engineering & Technology Activities.
Keywords: Engineering & Technology Activities, Loneliness, N-of-1 trials, real-world evidence, causal inference, observational study
Preliminary: Based on 3 participants. Results may change as more data is collected.
Results
Primary Findings
Analysis of 77 paired observations from 3 participants revealed a minimal improvement in Loneliness following above-average Engineering & Technology Activities exposure.
Supporting Statistics
What This Means
When participants had above-average Engineering & Technology Activities:
- Loneliness increased by 2.7% on average
- Temporal analysis supports Engineering & Technology Activities as the predictor (not the outcome)
Interpreting the Predictor Impact Score
The Predictor Impact Score (PIS) integrates multiple Bradford Hill causal criteria into a single metric. Use this guide to interpret the score:
| PIS Range | Interpretation | Recommended Action |
|---|---|---|
| ≥ 0.5 | Strong evidence | High priority for RCT validation |
| 0.3 - 0.5 | Moderate evidence | Consider for experimental investigation |
| 0.1 - 0.3 | Weak evidence | Monitor for additional data |
| < 0.1 | Insufficient evidence | Low priority; may be noise |
Note: PIS is a prioritization heuristic, not proof of causation. High scores indicate relationships worth investigating, not confirmed causal effects. With only 3 participants, these scores are preliminary and will become more reliable as additional data is collected.
Optimal Daily Values (Precision Dosing)
Based on the observed relationship, we can estimate the predictor values associated with the best and worst outcomes. These values enable personalized dosing recommendations.
⚠️ Preliminary Data: With 3 participants and 77 observations, these optimal values are preliminary estimates. As more data is collected, precision will improve significantly.
What This Suggests
Loneliness tended to be highest when Engineering & Technology Activities was around 0.2 h.
Important: These values reflect correlations, not guaranteed causal effects. Individual responses may vary. Use as a starting point for personal experimentation, not as a definitive prescription. Consult healthcare providers before making treatment decisions.
Population Correlation
Trait Correlation Between Engineering & Technology Activities and Loneliness
Engineering & Technology Activities Distribution
Daily Distribution
Average by Day of Week
Average by Month
Average by Year
Loneliness Distribution
Daily Distribution
Average by Day of Week
Average by Month
Average by Year
Statistical Summary
Relationship Statistics
| Property | Value |
|---|---|
| Cause Variable Name | Engineering & Technology Activities |
| Effect Variable Name | Loneliness |
| Sinn Predictive Coefficient | 0.018972106845498 |
| Confidence Level | LOW |
| Confidence Interval | 0.37985 |
| Forward Pearson Predictive Coefficient | 0.0732 |
| Critical T Value | 1.7 |
| Total Engineering & Technology Activities Over Previous 7 days Before ABOVE Average Loneliness | 8 minutes |
| Total Engineering & Technology Activities Over Previous 7 days Before BELOW Average Loneliness | 6 minutes |
| Duration of Action | 7 days |
| Effect Size | very weakly positive |
| Number of Paired Measurements | 77 |
| Optimal Pearson Product | 0.015997536197364 |
| P Value | 0.27962 |
| Statistical Significance | 0.3584 |
| Strength of Relationship | 0.37985 |
| Study Type | population |
| Analysis Performed At | 2026-01-04 |
| Number of Participants | 3 |
Engineering & Technology Activities Info
| Property | Value |
|---|---|
| Variable Name | Engineering & Technology Activities |
| Aggregation Method | SUM |
| Analysis Performed At | 2020-10-11 |
| Duration of Action | 7 days |
| Filling Value | 0 |
| Kurtosis | 192.59552148544 |
| Maximum Allowed Value | 7 days |
| Mean | 10 minutes |
| Median | 1 seconds |
| Minimum Allowed Value | 0 seconds |
| Number of Aggregate Predictors | 13 |
| Number of Aggregate Outcomes | 143 |
| Number of Measurements | 10323 |
| Number of Measurements (including those generated by tagged, joined, or child variables) | 2174 |
| Public | true |
| Onset Delay | 0 seconds |
| Standard Deviation | 0.6594650087989 |
| Unit | Hours |
| User Variables | 54 |
| Variable Category | Activities |
| Variable ID | 5956914 |
| Variance | 2.3524248751664 |
Loneliness Info
| Property | Value |
|---|---|
| Variable Name | Loneliness |
| Aggregation Method | MEAN |
| Analysis Performed At | 2020-10-11 |
| Duration of Action | 24 hours |
| Kurtosis | 1.7882861897431 |
| Maximum Allowed Value | 5 out of 5 |
| Mean | 3.1872105042017 out of 5 |
| Median | 3.1930393382353 out of 5 |
| Minimum Allowed Value | 1 out of 5 |
| Number of Aggregate Predictors | 437 |
| Number of Aggregate Outcomes | 167 |
| Number of Measurements | 3446 |
| Number of Measurements (including those generated by tagged, joined, or child variables) | 3182 |
| Public | true |
| Onset Delay | 0 seconds |
| Standard Deviation | 0.39907362842154 |
| Unit | 1 to 5 Rating |
| User Variables | 404 |
| UPC | 783324854602 |
| Variable Category | Emotions |
| Variable ID | 89438 |
| Variance | 0.44549918243977 |
Introduction
Background
Engineering & Technology Activities (Activities) and Loneliness (Emotions) are both important factors in understanding human health and well-being. This study investigates the relationship between these two variables using real-world observational data.
Traditional randomized controlled trials (RCTs), while the gold standard for causal inference, are often impractical, expensive, or unethical for studying many health relationships. Aggregated N-of-1 observational studies offer a complementary approach that leverages within-subject comparisons across large populations to identify meaningful patterns.
Research Question
Do Engineering & Technology Activities affect Loneliness?
Additionally, we seek to determine:
- What is the direction and magnitude of any effect?
- How confident can we be in this relationship based on the available data?
- What are the optimal levels of Engineering & Technology Activities for maximizing Loneliness?
Study Objective
The objective of this study is to determine the nature of the relationship (if any) between Engineering & Technology Activities and Loneliness. Additionally, we attempt to determine the Engineering & Technology Activities values most likely to produce optimal Loneliness values.
Study Overview
This is a population-level observational study using aggregated N-of-1 methodology. By aggregating individual N-of-1 experiments, we can identify population-level patterns while accounting for the substantial individual variation that exists in most health relationships. Effect sizes are reported as percent change from baseline, enabling intuitive interpretation and comparison across different measures.
Full Methodology: Framework for Real-World Evidence-Based Pharmacovigilance: Aggregated N-of-1 Trials for Quantifying Treatment Effects
Discussion
Interpretation of Findings
Participants experienced a 2.7% improvement in Loneliness following above-average Engineering & Technology Activities exposure. The Predictor Impact Score (PIS) of 0.02 indicates insufficient evidence for a causal relationship.
Statistical Significance
Using a two-tailed t-test with alpha = 0.05, it was determined that the change in Loneliness is not statistically significant at a 95% confidence interval. This suggests that the Engineering & Technology Activities value may not have a significant influence on the Loneliness value, or that more data is needed to detect an effect.
After treatment, a 2.2% increase (0.0898 out of 5) from the mean baseline 3.06 out of 5 was observed. The relative standard deviation at baseline was 26.7%. The observed change was 0.12485 times the standard deviation.
A common rule of thumb considers a change greater than twice the baseline standard deviation on two separate pre-post experiments may be considered significant. This occurrence would have only a 5% likelihood of resulting from random fluctuation (a p-value < 0.05).
T-Test Details
Since t = 0.75 < 1.70, we cannot reject the null hypothesis.
Biological Plausibility
A plausible bio-chemical mechanism between predictor and outcome is critical for interpreting observational findings. This is where human judgment excels beyond statistical analysis.
Community feedback on the biological plausibility of this relationship is still being collected. Consider the known mechanisms by which Engineering & Technology Activities might influence Loneliness.
Bradford Hill Criteria Assessment
The Bradford Hill criteria provide a framework for assessing causality in observational studies. Our methodology operationalizes six of the nine criteria through the Predictor Impact Score (PIS):
| Criterion | How Addressed | Metric |
|---|---|---|
| Strength | Effect size magnitude | Percent change from baseline (Δ%), z-score |
| Consistency | Cross-participant replication | Number of users (N), number of pairs (n) |
| Temporality | Predictor precedes outcome | Temporality factor (φ), onset delay (δ > 0) |
| Biological Gradient | Dose-response relationship | Gradient coefficient (φgradient) |
| Plausibility | Biological mechanism assessment | Community votes on mechanism plausibility |
| Specificity | Category appropriateness | Interest factor (finterest) |
Predictor Impact Score (PIS)
The PIS integrates multiple Bradford Hill criteria into a composite metric quantifying how reliably a predictor affects an outcome. Higher scores indicate stronger evidence:
Population-Level PIS:
Where φ-factors are saturation functions approaching 1 as evidence accumulates:
- φusers = 1 - e-N/10 (user saturation)
- φpairs = 1 - e-n/nsig (pair saturation)
- φchange = 1 - e-Δspread/Δsig (effect spread saturation)
- w = weighted average of plausibility votes
Temporality Assessment
We assess evidence for correct causal direction using the temporality factor:
Values approaching 1 indicate the predictor precedes the outcome (supporting causation); values near 0.5 suggest ambiguous directionality; values near 0 suggest reverse causation or confounding by indication.
Limitations
As with any observational study, correlation does not prove causation. Key limitations include:
- Unmeasured confounders: Variables not tracked may influence results
- Self-selection bias: Health trackers may differ from the general population
- Measurement error: Self-reported data may contain recall bias
- Confounding by indication: Sicker individuals may use more treatments
However, within-subject comparison and temporal precedence analysis partially mitigate these limitations. If the relationship is merely coincidental, as participants independently modify their Engineering & Technology Activities values, the observed strength will decline over time. Spurious correlations naturally dissipate as more data is collected.
Future Directions
Future research should examine:
- Subgroup analyses to identify individual differences in response
- Potential confounders and mediators of the observed relationship
- Optimal dosing and timing for Engineering & Technology Activities
- Confirmation through prospective or randomized designs
- Biological mechanisms underlying the observed effects
Conclusion
📊 Preliminary Findings: With 3 participants, these results are based on limited data. Effect sizes and confidence will improve as more participants contribute data. Consider these findings directional rather than definitive.
Above-average Engineering & Technology Activities was associated with a 2.7% improvement in Loneliness—a minimal effect. The Predictor Impact Score of 0.02 indicates this relationship is requiring additional data before conclusions.
Bottom Line: Based on a PIS of 0.02 and a 2.7% effect size, this relationship currently lacks sufficient evidence. Continue monitoring as more data becomes available. Note: These conclusions may strengthen or change direction as more data is collected.
These findings contribute to our understanding of how Engineering & Technology Activities may influence Loneliness in real-world conditions. While preliminary, these results may inform future research directions. As more participants contribute data, the reliability and precision of these findings will improve substantially.
Help End Unnecessary Suffering
Current clinical trials are 82x more expensive than necessary and take 17 years to bring treatments to market. Pragmatic trials integrated into standard healthcare could reduce costs from $41,000 to $500 per participant and compress timelines to just 2 years. Learn how redirecting just 1% of global military spending could accelerate cures for the 2 billion people suffering from treatable diseases.
Methods
Study Design
This study is based on data donated by 3 participants. Thus, the study design is equivalent to the aggregation of 3 separate n=1 observational natural experiments.
This within-subject design is powerful because it controls for all stable individual characteristics (genetics, baseline health status, socioeconomic factors) that might otherwise confound the relationship between variables.
Data Analysis
Temporal Assumptions
The analysis incorporates temporal assumptions about the relationship between variables:
- Onset Delay: It was assumed that 0 seconds would pass before a change in Engineering & Technology Activities would produce an observable change in Loneliness.
- Duration of Action: It was assumed that Engineering & Technology Activities could produce an observable change in Loneliness for as much as 7 days after the stimulus event.
Statistical Methods
For each participant, we calculated the Pearson correlation coefficient between Engineering & Technology Activities values and subsequent Loneliness values. Individual correlations were then aggregated using Fisher's z-transformation to produce a population-level estimate:
Individual Correlation:
Fisher's Z-Transformation:
Aggregated Correlation:
Effect Size Calculation
Effect sizes are reported as percent change from baseline. For each participant, we compare the outcome following above-average predictor values to the overall baseline outcome:
Effect Magnitude (Z-Score)
To assess effect magnitude relative to natural variability, we calculate the z-score:
where RSDbaseline is the relative standard deviation of outcome during baseline period
A z-score > 2 indicates statistical significance (p < 0.05), meaning the observed change exceeds typical baseline fluctuation and is unlikely due to random variation.
Statistical Significance
Correlation significance is assessed using a two-tailed t-test:
We reject the null hypothesis (ρ = 0) at α = 0.05 when |t| exceeds the critical value, providing statistical evidence that the observed relationship is not due to chance.
Data Sources
Engineering & Technology Activities data was primarily collected using RescueTime. Detailed reports show which applications and websites you spent time on. Activities are automatically grouped into pre-defined categories with built-in productivity scores covering thousands of websites and applications. You can customize categories and productivity scores to meet your needs.
Loneliness data was primarily collected using QuantiModo. QuantiModo allows you to easily track mood, symptoms, or any outcome you want to optimize in a fraction of a second. You can also import your data from over 30 other apps and devices. QuantiModo then analyzes your data to identify which hidden factors are most likely to be influencing your mood or symptoms.
Data Quality
Data quality measures were applied to ensure reliable results:
- Minimum Data Requirement: Only participants with sufficient paired observations were included in the analysis.
- Outlier Handling: Extreme values were winsorized to reduce the influence of measurement errors.
- Missing Data: Days with missing values were handled using appropriate filling strategies based on the variable type.
- Test User Exclusion: Test accounts and invalid users were excluded from all analyses.
Principal Investigator
Program & Methods
Cite This Study
@misc{sinn_cause_5956914_effect_89438_population_study_2026,
author = {Sinn, Mike P.},
title = {Causal Analysis: Does Engineering & Technology Activities Affect Loneliness?},
year = {2026},
publisher = {The Journal of Citizen Science},
url = {https://studies.crowdsourcingcures.org/study/cause-5956914-effect-89438-population-study},
note = {Accessed: January 6, 2026}
}
Study Type: Aggregated N-of-1 Observational Mega-Study
Evidence Level: Level II (Real-World Evidence)
Methodology: Bradford Hill Criteria with Predictor Impact Score (PIS)
References
This framework was originally developed in 2013 based on the Bradford Hill criteria. Subsequent literature has independently validated similar approaches to causal inference from observational data:
- Hill, A.B. (1965). The environment and disease: association or causation? Proceedings of the Royal Society of Medicine, 58(5), 295-300. [Bradford Hill criteria]
- Lillie, E.O., et al. (2011). The n-of-1 clinical trial: the ultimate strategy for individualizing medicine? Personalized Medicine, 8(2), 161-173. [N-of-1 methodology]
- Pearl, J. (2009). Causality: Models, Reasoning, and Inference . Cambridge University Press. [Causal inference]
- Hernán, M.A., & Robins, J.M. (2020). Causal Inference: What If . Chapman & Hall/CRC. [Free textbook]
- FDA (2018). Framework for FDA's Real-World Evidence Program . U.S. Food and Drug Administration. [Regulatory context]
- Duan, N., et al. (2013). Single-patient (n-of-1) trials: a pragmatic clinical decision methodology . Journal of Clinical Epidemiology, 66(8), S21-S28.
- Platt, R., et al. (2018). The FDA Sentinel Initiative—an evolving national resource . New England Journal of Medicine, 379(22), 2091-2093.
This information is for research and educational purposes only, not medical advice. Consult a healthcare provider before making health decisions. Terms of Service