Higher Sleep Quality Rating Predicts Very Slightly Lower Irritability for Population

Higher Sleep Quality Rating Predicts Very Slightly Lower Irritability for Population

Contents

Variables

A
Sleep Quality Rating 1835
A
Irritability 2164

Categories

A
Sleep 111
A
Emotions 2028

Actions

A
Join Study
A
Your Data

Tags

High Confidence
Very Weak Effect Size
Negative Relationship
Population Study
cause image gauge image effect image
Participants reported a 2.9% average decrease in Irritability following above average Sleep Quality Rating.

Abstract

Irritability was generally 3.64444% lower than average after 3.08 out of 5 of Sleep Quality Rating per 7 days.

Aggregated data from 9 study participants suggests with a HIGH degree of confidence (p=0.213, 95% CI -0.278 to 0.141) that Sleep Quality Rating has a very weakly negative predictive relationship (R=-0.0684) with Irritability.

The highest quartile of Irritability measurements were observed following an average 3.2 out of 5 Sleep Quality Rating.

The lowest quartile of Irritability measurements were observed following an average 3.25 out of 5 of Sleep Quality Rating.

After an onset delay of 0 seconds, Irritability is typically 1% lower than average over the 7 days following around 3.25 out of 5 of Sleep Quality Rating Sleep Quality Rating.

Keywords: Sleep Quality Rating, Irritability, N-of-1 trials, real-world evidence, causal inference, observational study

Preliminary: Based on 9 participants. Results may change as more data is collected.

Results

Primary Findings

Analysis of 667 paired observations from 9 participants revealed a minimal reduction in Irritability following above-average Sleep Quality Rating exposure.

-3.6%
Change from Baseline
Minimal effect on Irritability
0.63
Predictor Impact Score
Strong evidence for causal relationship

Supporting Statistics

High
Confidence
-0.068
Correlation (r)
p = 0.400
Significance
z = 0.45
Effect Magnitude
φ = 1.00
Temporality

What This Means

When participants had above-average Sleep Quality Rating:

  • Irritability decreased by 3.6% on average
  • The Predictor Impact Score of 0.63 suggests this relationship warrants high priority for experimental validation
  • Temporal analysis supports Sleep Quality Rating as the predictor (not the outcome)

Interpreting the Predictor Impact Score

The Predictor Impact Score (PIS) integrates multiple Bradford Hill causal criteria into a single metric. Use this guide to interpret the score:

PIS Range Interpretation Recommended Action
≥ 0.5 Strong evidence High priority for RCT validation
0.3 - 0.5 Moderate evidence Consider for experimental investigation
0.1 - 0.3 Weak evidence Monitor for additional data
< 0.1 Insufficient evidence Low priority; may be noise

Note: PIS is a prioritization heuristic, not proof of causation. High scores indicate relationships worth investigating, not confirmed causal effects. With only 9 participants, these scores are preliminary and will become more reliable as additional data is collected.

Optimal Daily Values

No clear dose-response relationship detected. The Sleep Quality Rating values associated with high and low Irritability are too similar to provide meaningful dosing guidance. This may indicate a threshold effect (any amount works equally well), no effect, or insufficient data variance. With more participants, a clearer pattern may emerge.

Population Correlation

Sleep Quality Rating Distribution

Irritability Distribution

Relationship Analysis

Statistical Summary

Relationship Statistics

Property Value
Cause Variable Name Sleep Quality Rating
Effect Variable Name Irritability
Sinn Predictive Coefficient 0.63402097732293
Confidence Level HIGH
Confidence Interval 0.20962600354865
Forward Pearson Predictive Coefficient -0.0684
Critical T Value 1.7147777777778
Average Sleep Quality Rating Over Previous 7 days Before ABOVE Average Irritability 3.2 out of 5
Average Sleep Quality Rating Over Previous 7 days Before BELOW Average Irritability 3.25 out of 5
Duration of Action 7 days
Effect Size very weakly negative
Number of Paired Measurements 667
Optimal Pearson Product 0.032784431025892
P Value 0.21255161845643
Statistical Significance 0.3999
Strength of Relationship 0.20962600354865
Study Type population
Analysis Performed At 2026-01-04
Number of Participants 9

Sleep Quality Rating Info

Property Value
Variable Name Sleep Quality Rating
Aggregation Method MEAN
Analysis Performed At 2020-10-11
Duration of Action 7 days
Kurtosis 2.5778129306718
Maximum Allowed Value 5 out of 5
Mean 2.9903634974079 out of 5
Median 3.024650617284 out of 5
Minimum Allowed Value 1 out of 5
Number of Aggregate Predictors 1714
Number of Aggregate Outcomes 121
Number of Measurements 7404
Number of Measurements (including those generated by tagged, joined, or child variables) 6498
Public true
Onset Delay 0 seconds
Standard Deviation 0.57066098706331
Unit 1 to 5 Rating
User Variables 83
UPC 675595199127
Variable Category Sleep
Variable ID 5953225
Variance 0.46612568222008

Irritability Info

Property Value
Variable Name Irritability
Aggregation Method MEAN
Analysis Performed At 2021-04-24
Duration of Action 24 hours
Kurtosis 1.9396417204894
Maximum Allowed Value 5 out of 5
Mean 2.5563854177215 out of 5
Median 2.5011050632911 out of 5
Minimum Allowed Value 1 out of 5
Number of Aggregate Predictors 1940
Number of Aggregate Outcomes 224
Number of Measurements 48786
Number of Measurements (including those generated by tagged, joined, or child variables) 48786
Public true
Onset Delay 0 seconds
Standard Deviation 0.55855204814277
Unit 1 to 5 Rating
User Variables 2228
UPC 0
Variable Category Emotions
Variable ID 1358
Variance 0.64983545400519

Introduction

Background

Sleep Quality Rating (Sleep) and Irritability (Emotions) are both important factors in understanding human health and well-being. This study investigates the relationship between these two variables using real-world observational data.

Traditional randomized controlled trials (RCTs), while the gold standard for causal inference, are often impractical, expensive, or unethical for studying many health relationships. Aggregated N-of-1 observational studies offer a complementary approach that leverages within-subject comparisons across large populations to identify meaningful patterns.

Research Question

Does Sleep Quality Rating affect Irritability?

Additionally, we seek to determine:

  1. What is the direction and magnitude of any effect?
  2. How confident can we be in this relationship based on the available data?
  3. What are the optimal levels of Sleep Quality Rating for maximizing Irritability?

Study Objective

The objective of this study is to determine the nature of the relationship (if any) between Sleep Quality Rating and Irritability. Additionally, we attempt to determine the Sleep Quality Rating values most likely to produce optimal Irritability values.

Study Overview

This is a population-level observational study using aggregated N-of-1 methodology. By aggregating individual N-of-1 experiments, we can identify population-level patterns while accounting for the substantial individual variation that exists in most health relationships. Effect sizes are reported as percent change from baseline, enabling intuitive interpretation and comparison across different measures.

Full Methodology: Framework for Real-World Evidence-Based Pharmacovigilance: Aggregated N-of-1 Trials for Quantifying Treatment Effects

Discussion

Interpretation of Findings

Participants experienced a 3.6% reduction in Irritability following above-average Sleep Quality Rating exposure. The Predictor Impact Score (PIS) of 0.63 indicates strong evidence for a causal relationship.

Statistical Significance

Using a two-tailed t-test with alpha = 0.05, it was determined that the change in Irritability is not statistically significant at a 95% confidence interval. This suggests that the Sleep Quality Rating value may not have a significant influence on the Irritability value, or that more data is needed to detect an effect.

After treatment, a 2.9% decrease (-0.092 out of 5) from the mean baseline 2.04 out of 5 was observed. The relative standard deviation at baseline was 20.3111%. The observed change was 0.447107 times the standard deviation.

A common rule of thumb considers a change greater than twice the baseline standard deviation on two separate pre-post experiments may be considered significant. This occurrence would have only a 5% likelihood of resulting from random fluctuation (a p-value < 0.05).

T-Test Details
Observed t-value: 1.129
Critical t-value: 1.715

Since t = 1.13 < 1.71, we cannot reject the null hypothesis.

Biological Plausibility

A plausible bio-chemical mechanism between predictor and outcome is critical for interpreting observational findings. This is where human judgment excels beyond statistical analysis.

Based on community responses so far, 1 person feels that there is a plausible mechanism of action and 0 feel that any relationship observed between Sleep Quality Rating and Irritability is coincidental.

Bradford Hill Criteria Assessment

The Bradford Hill criteria provide a framework for assessing causality in observational studies. Our methodology operationalizes six of the nine criteria through the Predictor Impact Score (PIS):

Criterion How Addressed Metric
Strength Effect size magnitude Percent change from baseline (Δ%), z-score
Consistency Cross-participant replication Number of users (N), number of pairs (n)
Temporality Predictor precedes outcome Temporality factor (φ), onset delay (δ > 0)
Biological Gradient Dose-response relationship Gradient coefficient (φgradient)
Plausibility Biological mechanism assessment Community votes on mechanism plausibility
Specificity Category appropriateness Interest factor (finterest)

Predictor Impact Score (PIS)

The PIS integrates multiple Bradford Hill criteria into a composite metric quantifying how reliably a predictor affects an outcome. Higher scores indicate stronger evidence:

Population-Level PIS:

$$\text{PIS}_{\text{agg}} = |r_{\text{forward}}| \cdot w \cdot \phi_{\text{users}} \cdot \phi_{\text{pairs}} \cdot \phi_{\text{change}} \cdot \phi_{\text{gradient}}$$

Where φ-factors are saturation functions approaching 1 as evidence accumulates:

  • φusers = 1 - e-N/10 (user saturation)
  • φpairs = 1 - e-n/nsig (pair saturation)
  • φchange = 1 - e-Δspread/Δsig (effect spread saturation)
  • w = weighted average of plausibility votes

Temporality Assessment

We assess evidence for correct causal direction using the temporality factor:

$$\phi_{\text{temporal}} = \frac{|r_{\text{forward}}|}{|r_{\text{forward}}| + |r_{\text{reverse}}|}$$

Values approaching 1 indicate the predictor precedes the outcome (supporting causation); values near 0.5 suggest ambiguous directionality; values near 0 suggest reverse causation or confounding by indication.

Limitations

As with any observational study, correlation does not prove causation. Key limitations include:

  • Unmeasured confounders: Variables not tracked may influence results
  • Self-selection bias: Health trackers may differ from the general population
  • Measurement error: Self-reported data may contain recall bias
  • Confounding by indication: Sicker individuals may use more treatments

However, within-subject comparison and temporal precedence analysis partially mitigate these limitations. If the relationship is merely coincidental, as participants independently modify their Sleep Quality Rating values, the observed strength will decline over time. Spurious correlations naturally dissipate as more data is collected.

Future Directions

Future research should examine:

  • Subgroup analyses to identify individual differences in response
  • Potential confounders and mediators of the observed relationship
  • Optimal dosing and timing for Sleep Quality Rating
  • Confirmation through prospective or randomized designs
  • Biological mechanisms underlying the observed effects

Conclusion

📊 Preliminary Findings: With 9 participants, these results are based on limited data. Effect sizes and confidence will improve as more participants contribute data. Consider these findings directional rather than definitive.

Above-average Sleep Quality Rating was associated with a 3.6% reduction in Irritability—a minimal effect. The Predictor Impact Score of 0.63 indicates this relationship is high priority for experimental validation.

Bottom Line: Based on a PIS of 0.63 and a 3.6% effect size, this relationship shows strong evidence and should be prioritized for experimental validation through randomized controlled trials. Note: These conclusions may strengthen or change direction as more data is collected.

These findings contribute to our understanding of how Sleep Quality Rating may influence Irritability in real-world conditions. The combination of effect size, sample size, and temporal evidence supports this as a meaningful relationship worth investigating further.

Help End Unnecessary Suffering

Current clinical trials are 82x more expensive than necessary and take 17 years to bring treatments to market. Pragmatic trials integrated into standard healthcare could reduce costs from $41,000 to $500 per participant and compress timelines to just 2 years. Learn how redirecting just 1% of global military spending could accelerate cures for the 2 billion people suffering from treatable diseases.

Make Suffering Optional

Methods

Study Design

This study is based on data donated by 9 participants. Thus, the study design is equivalent to the aggregation of 9 separate n=1 observational natural experiments.

This within-subject design is powerful because it controls for all stable individual characteristics (genetics, baseline health status, socioeconomic factors) that might otherwise confound the relationship between variables.

Data Analysis

Temporal Assumptions

The analysis incorporates temporal assumptions about the relationship between variables:

  • Onset Delay: It was assumed that 0 seconds would pass before a change in Sleep Quality Rating would produce an observable change in Irritability.
  • Duration of Action: It was assumed that Sleep Quality Rating could produce an observable change in Irritability for as much as 7 days after the stimulus event.

Statistical Methods

For each participant, we calculated the Pearson correlation coefficient between Sleep Quality Rating values and subsequent Irritability values. Individual correlations were then aggregated using Fisher's z-transformation to produce a population-level estimate:

Individual Correlation:

$$r_i = \frac{\sum(x_{ij} - \bar{x}_i)(y_{ij} - \bar{y}_i)}{\sqrt{\sum(x_{ij} - \bar{x}_i)^2 \sum(y_{ij} - \bar{y}_i)^2}}$$

Fisher's Z-Transformation:

$$z_i = \frac{1}{2} \ln\left(\frac{1 + r_i}{1 - r_i}\right)$$

Aggregated Correlation:

$$\bar{r} = \tanh(\bar{z}) \quad \text{where} \quad \bar{z} = \frac{1}{N}\sum_{i=1}^{N} z_i$$

Effect Size Calculation

Effect sizes are reported as percent change from baseline. For each participant, we compare the outcome following above-average predictor values to the overall baseline outcome:

$$\Delta\%_{\text{baseline}} = \frac{\bar{O}_{\text{follow-up}} - \bar{O}_{\text{baseline}}}{\bar{O}_{\text{baseline}}} \times 100$$

Effect Magnitude (Z-Score)

To assess effect magnitude relative to natural variability, we calculate the z-score:

$$z = \frac{|\Delta\%_{\text{baseline}}|}{\text{RSD}_{\text{baseline}}}$$

where RSDbaseline is the relative standard deviation of outcome during baseline period

A z-score > 2 indicates statistical significance (p < 0.05), meaning the observed change exceeds typical baseline fluctuation and is unlikely due to random variation.

Statistical Significance

Correlation significance is assessed using a two-tailed t-test:

$$t = \frac{r\sqrt{n-2}}{\sqrt{1-r^2}}$$

We reject the null hypothesis (ρ = 0) at α = 0.05 when |t| exceeds the critical value, providing statistical evidence that the observed relationship is not due to chance.

Data Sources

Sleep Quality Rating data was primarily collected using QuantiModo. QuantiModo allows you to easily track mood, symptoms, or any outcome you want to optimize in a fraction of a second. You can also import your data from over 30 other apps and devices. QuantiModo then analyzes your data to identify which hidden factors are most likely to be influencing your mood or symptoms.

Irritability data was primarily collected using QuantiModo. QuantiModo allows you to easily track mood, symptoms, or any outcome you want to optimize in a fraction of a second. You can also import your data from over 30 other apps and devices. QuantiModo then analyzes your data to identify which hidden factors are most likely to be influencing your mood or symptoms.

Data Quality

Data quality measures were applied to ensure reliable results:

  • Minimum Data Requirement: Only participants with sufficient paired observations were included in the analysis.
  • Outlier Handling: Extreme values were winsorized to reduce the influence of measurement errors.
  • Missing Data: Days with missing values were handled using appropriate filling strategies based on the variable type.
  • Test User Exclusion: Test accounts and invalid users were excluded from all analyses.

Principal Investigator

Program & Methods

Mike P. Sinn
Sinn, M. P.

Designed and implemented data collection, aggregation, causal inference pipeline, and automated study generation framework. Developed the Predictor Impact Score methodology operationalizing Bradford Hill criteria for ranking causal relationships in observational data. When he tells people this at parties, they usually say they have to go check on their car.

Individual study outputs are automated, reproducible, and open to external audit. (Which I would seriously recommend.)

Contact

Cite This Study

APA Format
Sinn, M. P. (2026). Causal Analysis: Does Sleep Quality Rating Affect Irritability?. The Journal of Citizen Science. https://studies.crowdsourcingcures.org/study/cause-5953225-effect-1358-population-study
BibTeX 
@misc{sinn_cause_5953225_effect_1358_population_study_2026,
  author = {Sinn, Mike P.},
  title = {Causal Analysis: Does Sleep Quality Rating Affect Irritability?},
  year = {2026},
  publisher = {The Journal of Citizen Science},
  url = {https://studies.crowdsourcingcures.org/study/cause-5953225-effect-1358-population-study},
  note = {Accessed: January 9, 2026}
}
Chicago/Turabian
Sinn, Mike P. "Causal Analysis: Does Sleep Quality Rating Affect Irritability?." The Journal of Citizen Science. Accessed January 9, 2026. https://studies.crowdsourcingcures.org/study/cause-5953225-effect-1358-population-study.
Harvard
Sinn, M.P., 2026. Causal Analysis: Does Sleep Quality Rating Affect Irritability?. [Aggregated N-of-1 Study] The Journal of Citizen Science. Available at: https://studies.crowdsourcingcures.org/study/cause-5953225-effect-1358-population-study [Accessed January 9, 2026].

Study Type: Aggregated N-of-1 Observational Mega-Study
Evidence Level: Level II (Real-World Evidence)
Methodology: Bradford Hill Criteria with Predictor Impact Score (PIS)

References

This framework was originally developed in 2013 based on the Bradford Hill criteria. Subsequent literature has independently validated similar approaches to causal inference from observational data:

  1. Hill, A.B. (1965). The environment and disease: association or causation? Proceedings of the Royal Society of Medicine, 58(5), 295-300. [Bradford Hill criteria]
  2. Lillie, E.O., et al. (2011). The n-of-1 clinical trial: the ultimate strategy for individualizing medicine? Personalized Medicine, 8(2), 161-173. [N-of-1 methodology]
  3. Pearl, J. (2009). Causality: Models, Reasoning, and Inference . Cambridge University Press. [Causal inference]
  4. Hernán, M.A., & Robins, J.M. (2020). Causal Inference: What If . Chapman & Hall/CRC. [Free textbook]
  5. FDA (2018). Framework for FDA's Real-World Evidence Program . U.S. Food and Drug Administration. [Regulatory context]
  6. Duan, N., et al. (2013). Single-patient (n-of-1) trials: a pragmatic clinical decision methodology . Journal of Clinical Epidemiology, 66(8), S21-S28.
  7. Platt, R., et al. (2018). The FDA Sentinel Initiative—an evolving national resource . New England Journal of Medicine, 379(22), 2091-2093.

This information is for research and educational purposes only, not medical advice. Consult a healthcare provider before making health decisions. Terms of Service

LinkedIn Reddit