Higher Blood Pressure (Systolic - Top Number) Predicts Slightly Lower Daily Step Count for Population
Contents
Mike Sinn
PRINCIPAL INVESTIGATOR
Mike Sinn

Variables

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Blood Pressure 897
A
Steps 331

Categories

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Vital Signs 110
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Physical Activity 1719

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Medium Confidence
Very Weak Effect Size
Negative Relationship
Population Study
cause image gauge image effect image
Participants reported a 33% average decrease in Daily Step Count following above average Blood Pressure (Systolic - Top Number).
Abstract

Abstract

Daily Step Count was generally 13% higher than average after an average of 135 millimeters merc of Blood Pressure over the previous 7 days.

Aggregated data from 3 study participants suggests with a MEDIUM degree of confidence (p=0.247, 95% CI -15948.279 to 15948.045) that Blood Pressure has a weakly negative predictive relationship (R=-0.117) with Daily Step Count.

The highest quartile of Daily Step Count measurements were observed following an average 131 millimeters merc Blood Pressure.

The lowest quartile of Daily Step Count measurements were observed following an average 133 millimeters merc of Blood Pressure.

After an onset delay of 0 seconds, Daily Step Count is typically 13% lower than average over the 7 days following around 133 millimeters merc Blood Pressure.

Objective

Objective

The objective of this study is to determine the nature of the relationship (if any) between Blood Pressure and Daily Step Count. Additionally, we attempt to determine the Blood Pressure (Systolic - Top Number) values most likely to produce optimal Daily Step Count values.
Participant Instructions

Participant Instructions

Blood Pressure (Systolic - Top Number) Automatic Import of Blood Pressure via Withings

A Get Withings here and use it to record your Blood Pressure. Then, A import your data here .

Manual Recording Option

A Create a reminder for Blood Pressure here and record it daily by enabling notifications or using A the reminder inbox here .


Daily Step Count Automatic Import of Steps via Fitbit

A Get Fitbit here and use it to record your Steps. Then, A import your data here .

Manual Recording Option

A Create a reminder for Steps here and record it daily by enabling notifications or using A the reminder inbox here .

Daily Step Count Automatic Import of Steps via Withings

A Get Withings here and use it to record your Steps. Then, A import your data here .

Design

Design

This study is based on data donated by 3 participants. Thus, the study design is equivalent to the aggregation of 3 separate n=1 observational natural experiments.

Data Analysis

Data Analysis

Blood Pressure Pre-Processing

Blood Pressure measurement values below 1 millimeters merc were assumed erroneous and removed. Blood Pressure measurement values above 100000 millimeters merc were assumed erroneous and removed. No missing data filling value was defined for Blood Pressure so any gaps in data were just not analyzed instead of assuming zero values for those times.

Steps Pre-Processing

Steps measurement values below 1 count were assumed erroneous and removed. No maximum allowed measurement value was defined for Steps. No missing data filling value was defined for Steps so any gaps in data were just not analyzed instead of assuming zero values for those times.

Predictive Analytics

It was assumed that 0 seconds would pass before a change in Blood Pressure (Systolic - Top Number) would produce an observable change in Daily Step Count.

It was assumed that Blood Pressure (Systolic - Top Number) could produce an observable change in Daily Step Count for as much as 7 days after the stimulus event.

Statistical Significance

Statistical Significance

Using a two-tailed t-test with alpha = 0.05, it was determined that the change in Daily Step Count is not statistically significant at a 95% confidence interval. This suggests that the Blood Pressure value does not have a significant influence on the Daily Step Count value.

After treatment, a 33% decrease (-20600 count) from the mean baseline 59800 count was observed. The relative standard deviation at baseline was 71.3333%. The observed change was 0.684876 times the standard deviation.

A common rule of thumb considers a change greater than twice the baseline standard deviation on two separate pre-post experiments may be considered significant. This occurrence would have only a 5% likelihood of resulting from random fluctuation (a p-value < 0.05).

Data Sources

Data Sources

Blood Pressure (Systolic - Top Number) data was primarily collected using Withings. Withings creates smart products and apps to take care of yourself and your loved ones in a new and easy way. Discover the Withings Pulse, Wi-Fi Body Scale, and Blood Pressure Monitor.

Daily Step Count data was primarily collected using Fitbit. Fitbit makes activity tracking easy and automatic.

Limitations

Limitations

As with any human experiment, it was impossible to control for all potentially confounding variables. Correlation does not necessarily imply causation. We can never know for sure if one factor is definitely the cause of an outcome. However, lack of correlation definitely implies the lack of a causal relationship. Hence, we can with great confidence rule out non-existent relationships. For instance, if we discover no relationship between mood and an antidepressant this information is just as or even more valuable than the discovery that there is a relationship.

We can also take advantage of several characteristics of time series data from many subjects to infer the likelihood of a causal relationship if we do find a correlational relationship. The criteria for causation are a group of minimal conditions necessary to provide adequate evidence of a causal relationship between an incidence and a possible consequence.

Criteria For Causal Inference

Strength (A.K.A. Effect Size)

A small association does not mean that there is not a causal effect, though the larger the association, the more likely that it is causal. There is a weakly negative (R = -0.1166) relationship between Blood Pressure (Systolic - Top Number) and Daily Step Count.

Consistency (A.K.A. Reproducibility)

Consistent findings observed by different persons in different places with different samples strengthens the likelihood of an effect. Furthermore, in accordance with the law of large numbers (LLN), the predictive power and accuracy of these results will continually grow over time. 121 paired data points were used in this analysis. Assuming that the relationship is merely coincidental, as the participant independently modifies their Blood Pressure (Systolic - Top Number) values, the observed strength of the relationship will decline until it is below the threshold of significance. To it another way, in the case that we do find a spurious correlation, suggesting that banana intake improves mood for instance, one will likely increase their banana intake. Due to the fact that this correlation is spurious, it is unlikely that you will see a continued and persistent corresponding increase in mood. So over time, the spurious correlation will naturally dissipate.

Specificity

Causation is likely if a very specific population at a specific site and disease with no other likely explanation. The more specific an association between a factor and an effect is, the bigger the probability of a causal relationship.

Temporality

The effect has to occur after the cause (and if there is an expected delay between the cause and expected effect, then the effect must occur after that delay). The confidence in a causal relationship is bolstered by the fact that time-precedence was taken into account in all calculations.

Biological Gradient

Greater exposure should generally lead to greater incidence of the effect. However, in some cases, the mere presence of the factor can trigger the effect. In other cases, an inverse proportion is observed: greater exposure leads to lower incidence.

Plausibility

A plausible bio-chemical mechanism between cause and effect is critical. This is where human brains excel.

Based on our responses so far,

0 humans feel that there is a plausible mechanism of action for a relationship between Blood Pressure (Systolic - Top Number) and Daily Step Count.

0 humans feel that any relationship observed between Blood Pressure (Systolic - Top Number) and Daily Step Count is coincidental.

Coherence

Coherence between epidemiological and laboratory findings increases the likelihood of an effect. It will be very enlightening to aggregate this data with the data from other participants with similar genetic, diseasomic, environmentomic, and demographic profiles.

Experiment

All of human life can be considered a natural experiment. Occasionally, it is possible to appeal to experimental evidence.

Analogy

The effect of similar factors may be considered.

Plausibility

Plausibility

A plausible bio-chemical mechanism between cause and effect is critical. This is where human brains excel. Based on our responses so far, 0 humans feel that there is a plausible mechanism of action and 0 feel that any relationship observed between Blood Pressure (Systolic - Top Number) and Daily Step Count is coincidental.

Relationship Statistics

Property Value
Cause Variable Name Blood Pressure (Systolic - Top Number)
Effect Variable Name Daily Step Count
Sinn Predictive Coefficient 0.015110297652379
Confidence Level MEDIUM
Confidence Interval 15948.161925329
Forward Pearson Predictive Coefficient -0.1166
Critical T Value 1.6826666666667
Average Blood Pressure ( Systolic - Top Number) Over Previous 7 days Before ABOVE Average Daily Step Count 131 millimeters merc
Average Blood Pressure ( Systolic - Top Number) Over Previous 7 days Before BELOW Average Daily Step Count 133 millimeters merc
Duration of Action 7 days
Effect Size weakly negative
Number of Paired Measurements 121
Optimal Pearson Product 0.036578183720577
P Value 0.2471230177924
Statistical Significance 0.5191
Strength of Relationship 15948.161925329
Study Type population
Analysis Performed At 2021-08-30
Number of Participants 3

Blood Pressure Info

Property Value
Variable Name Blood Pressure (Systolic - Top Number)
Aggregation Method MEAN
Analysis Performed At 2020-09-15
Duration of Action 7 days
Kurtosis 9.6485959987812
Maximum Allowed Value 100000 millimeters merc
Mean 4546.9564108281 millimeters merc
Median 4547.0725028058 millimeters merc
Minimum Allowed Value 1 millimeters merc
Number of Aggregate Predictors 780
Number of Aggregate Outcomes 117
Number of Measurements 8517
Number of Measurements (including those generated by tagged, joined, or child variables) 5176
Public true
Onset Delay 0 seconds
Standard Deviation 31.78039339699
Unit Millimeters Merc
User Variables 61
UPC 647679244474
Variable Category Vital Signs
Variable ID 1874
Variance 23939.264480794

Steps Info

Property Value
Variable Name Daily Step Count
Aggregation Method SUM
Analysis Performed At 2020-10-11
Duration of Action 7 days
Kurtosis 16.639977980211
Mean 6466.3629645193 count
Median 6036.923245614 count
Minimum Allowed Value 1 count
Number of Aggregate Predictors 131
Number of Aggregate Outcomes 200
Number of Measurements 88028
Number of Measurements (including those generated by tagged, joined, or child variables) 10365
Public true
Onset Delay 0 seconds
Standard Deviation 3084.0373174008
Unit Count
User Variables 280
UPC 734010049130
Variable Category Physical Activity
Variable ID 1451
Variance 12961277.144652